Registre National des Cancers de l’Enfant

ESTELLE STUDY

ESTELLE - Case-control study on childhood cancers (leukaemias, lymphomas, brain tumours, neuroblastomas, nephroblastomas, hepatoblastomas).

Investigators Jacqueline Clavel, Jérémie Rudant- INSERM UMRS 1153 – team EPICEA
Period 2010-2011
Objectives

- To analyse the association between the risk of childhood cancers and the events of pregnancy, the child’s characteristics at birth, the environment in foetal period and early childhood, exposures related to the parents’ occupation or lifestyle, or related to the home location, a family history of cancer, congenital malformations, or autoimmune diseases.

 - To identify genetic factors that may modulate the role of these factors, including polymorphisms in genes involved in xenobiotic transport and metabolism, DNA repair, immune response, or foetal growth and cell differentiation.- To analyse the interactions between all these polymorphisms and environmental factors.

Collaborations

SFCE, Services d’hémato-oncologie et de neurochirurgie pédiatriques,
CRB Epigenetec (INSERM U775), IPSOS, Geocible, Integragen
Caroline Besson (Inserm U802), Judith Landman-Parker (Hôpital Trousseau), Isabelle Janoueix (Inserm U830)

Funding INCa, Ligue Nationale contre le Cancer, Enfants et Santé, DHOS
Statutory approval CNIL (908283) – avis favorable CPP Ile de France IV, 2008/12NICB (hors RBM)
Methods

ESTELLE study was conducted in 2010-2011 all over mainland France, following to the methods of the previous study ESCALE.

The study  included :

-        1,814 cases diagnosed with either leukaemia (740), Hodgkin lymphoma (206), non-Hodgkin lymphoma (174), brain tumour (339), neuroblastoma (201), nephroblastoma (134), or hepatoblastoma (22) before the age of 15 years.

-        1,423 controls of the same age and of the same sex, on average, as the cases, selected by frequency-matching in the general population.

The biological mothers of cases and controls were interviewed by phone, in a standardised way, and asked about the child’s individual and familial medical history and  environment.

A biological sampling was performed subject to the informed consent of the parents. It consisted of a blood (for cases) or saliva sample (controls, case parents, and relatives if there was a specific medical family history).

Results

Analyses are ongoing. For some cancer types, the ESTELLE data will be analysed together with the data from the previous study ESCALE.

Publications

Ajrouche R, Rudant J, Orsi L, Petit A, Baruchel A, Nelken B, Pasquet M, Michel G, Bergeron C, Ducassou S, Gandemer V, Lutz P, Saumet L, Rialland X, Hémon D, Clavel J. Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: The ESTELLE study. Cancer Causes Control. 25(10):1283-93. (2014)

Ajrouche R, Rudant J, Orsi L, Petit A, Baruchel A, Lambilliotte A, Gambart M, Michel G, Bertrand Y, Ducassou S, Gandemer V, Paillard C, Saumet L, Blin N, Hémon D, Clavel J. Childhood acute lymphoblastic leukaemia and indicators of early immune stimulation: The estelle study (SFCE). Br J Cancer. 112(6):1017-26. (2015)

Orsi L, Rudant J, Ajrouche R, Leverger G, Baruchel A, Nelken B, Pasquet M, Michel G, Bertrand Y, Ducassou S, Gandemer V, Lutz P, Saumet L, Moreau P, Hemon D, Clavel J. Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: The ESTELLE study. Cancer Causes Control. 26(7):1003-17. (2015)

Rios P, Bailey HD, Orsi L, Lacour B, Valteau-Couanet D, Levy D, Corradini N, Leverger G, Defachelles AS, Gambart M, Sirvent N, Thebaud E, Ducassou S, Clavel J. Risk of neuroblastoma, birth-related characteristics, congenital malformations and perinatal exposures: A pooled analysis of the ESCALE and ESTELLE French studies (SFCE). Int J Cancer. 139(9):1936-48. (2016)

Rios P, Bailey HD, Lacour B, Valteau-Couanet D, Michon J, Bergeron C, Boutroux H, Defachelles AS, Gambart M, Sirvent N, Thebaud E, Ducassou S, Orsi L, Clavel J. Cancer Causes Control. Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE). Epub ahead of print 10.1007/s10552-017-0944-5 (2017)

Bailey HD, Lacour B, Guerrini-Rousseau L, Bertozzi A, Leblond P, Faure-Conter C, Pellier I, Freycon C, Doz F, Puget S, Ducassou S, Orsi L, Clavel J. Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France). Cancer Causes Control. 28(7):719-32 (2017)

Bailey HD, Rios P, Lacour B, Guerrini-Rousseau L, Bertozzi AI, Leblond P, Faure-Conter C, Pellier I, Freycon C, Michon J, Puget S, Ducassou S, Orsi L, Clavel J. Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France) Int J Cancer. 140(8):1757-69. (2017)

PhDs

Roula Ajrouche, « Facteurs de risque des leucémies de l'enfant » (dir. J. Rudant et J. Clavel), Université Paris-Sud, defended in 2015

Paula Rios, «Facteurs de risque environnementaux et périnataux des neuroblastomes de l'enfant » (dir. J. Clavel), Université Paris-Descartes, defended in 2019

Nicolas Vidart, «Facteurs de risque environnementaux des tumeurs cérébrales de l'enfant » (dir. J. Clavel), Université Paris-Descartes, defended in 2019

Villejuif

INSERM
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+33 (0)1 45 59 50 37
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Nancy

Faculté de Médecine
BP 20199
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54505 Vandoeuvre les Nancy Cedex

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rntse@inserm.fr